Crohn’s Disease

In a randomized trial of 191 adults with mild-to-moderate Crohn’s disease symptoms, the Specific Carbohydrate Diet was not superior to a Mediterranean diet for symptomatic remission, fecal calprotectin response, or CRP response after six weeks.

• Symptomatic remission does not establish mucosal healing or cure.
• CRP response was uncommon.
• Do not claim the Mediterranean diet induces remission in all patients.
• Do not imply diet replaces standard Crohn’s disease medical therapy.

Not established by this trial.

• Source 1: https://pubmed.ncbi.nlm.nih.gov/34052278/

Systematic reviews find some promising results for Mediterranean-style and Crohn’s disease exclusion diets in mild-to-moderate Crohn’s disease, but certainty is limited by small studies, heterogeneous interventions, and moderate-to-high risk of bias.

• Evidence is insufficient to recommend one universal therapeutic diet.
• Clinical symptom improvement should not be equated with endoscopic healing.
• Do not claim dietary therapy cures Crohn’s disease or replaces medication.

Not established.

• Source 1: https://pubmed.ncbi.nlm.nih.gov/39107691/
• Source 2: https://pubmed.ncbi.nlm.nih.gov/36470529/