Prediabetes

Randomized-trial meta-analyses show structured lifestyle interventions involving diet, physical activity, and related behavior changes can reduce progression from prediabetes to Type 2 Diabetes. Effects vary according to prediabetes phenotype and intervention characteristics.

• Benefit varies by prediabetes phenotype.
• Do not assume identical benefit for isolated impaired fasting glucose, impaired glucose tolerance, or elevated HbA1c.
• Lifestyle intervention is multidimensional, so effects should not be attributed to one food or dietary component.
• Do not describe prediabetes as universally reversible.
• Do not imply lifestyle intervention guarantees prevention of Type 2 Diabetes.

Reduced progression to Type 2 Diabetes is supported, but magnitude varies by population and intervention.

• Source 1: https://pubmed.ncbi.nlm.nih.gov/39778431/
• Source 2: https://pubmed.ncbi.nlm.nih.gov/38548107/

A meta-analysis of 44 randomized trials involving 14,742 participants with prediabetes found lifestyle weight-loss interventions increased regression to normoglycemia and reduced progression to Type 2 Diabetes over a median intervention duration of 24 months.

• Regression to normoglycemia is the measured glycemic state and must not be described as a permanent cure or reversal.
• Weight-loss interventions included diet, exercise, and combinations.
• Individual responses vary.
• Do not prescribe a specific weight-loss target based solely on this evidence.
• Do not imply normoglycemia eliminates future diabetes risk.

Reduced progression to Type 2 Diabetes is supported during studied follow-up. Permanent prevention is not established.

• Source 1: https://pubmed.ncbi.nlm.nih.gov/39222689/