Ulcerative Colitis

A small 12-week randomized controlled trial in adults with quiescent ulcerative colitis found a Mediterranean dietary pattern was well tolerated and was associated with more favorable fecal-calprotectin findings and microbiome changes compared with participants following their habitual Canadian diet.

• Small sample size.
• Participants had quiescent ulcerative colitis.
• Fecal calprotectin is a biomarker and must not be equated with cure or durable remission.
• Microbiome changes are mechanistic findings, not proof of long-term clinical benefit.
• Do not claim the Mediterranean diet replaces standard ulcerative-colitis therapy.

Not established.

• Source 1: https://pubmed.ncbi.nlm.nih.gov/37095601/

A systematic review of 14 randomized trials found dietary interventions may influence clinical response and remission outcomes in ulcerative colitis, but results vary substantially by intervention and the evidence base remains heterogeneous.

• Dietary interventions differed substantially across studies.
• Several specific elimination or anti-inflammatory diets did not show significant advantages for maintaining remission.
• Evidence should not be generalized into a single therapeutic ulcerative-colitis diet.
• Do not claim dietary intervention cures ulcerative colitis.
• Do not imply diet replaces medication or specialist management.

Not established.

• Source 1: https://pubmed.ncbi.nlm.nih.gov/37836478/